Libertad | 5 - 0 | Club River Plate | 03/12/2021 23:30 |
12 de Octubre | 1 - 0 | Sol de America | 04/12/2021 22:15 |
Sportivo Luqueno | 0 - 1 | Guairena | 04/12/2021 22:15 |
Club Guarani | 2 - 2 | Cerro Porteno | 05/12/2021 00:30 |
Nacional Asuncion | 1 - 3 | Olimpia Asuncion | 05/12/2021 23:30 |